It depends on what the number is associated with.

The number 143, as itself, has no significance other than the context with what it represents.

The essence of the number 143 has much to do with managing material abundance. Also with a tendency to do it by itself rather than delegating important tasks.

If the number is associated with the life path position of a person's numerology chart, it represents situations and events having to do with opportunities for material gain. On the other hand, if 143 represents the heart's desire position, it represents a yearning never completely fulfilled to be independent and well-to-do.

Similarly with other chart positions, the essence of the number is used to determine the significance or meaning within the context.